https://www.sciencedaily.com/news/health_medicine/epigenetics/ Read the latest research news on epigenetics, epigenetic influences on disease risk and gene silencing. en-us Thu, 24 Sep 2026 00:06:42 EDT Thu, 24 Sep 2026 00:06:42 EDT 60 https://www.sciencedaily.com/images/scidaily-logo-rss.png https://www.sciencedaily.com/news/health_medicine/epigenetics/ For more science news, visit ScienceDaily. https://www.sciencedaily.com/releases/2026/09/260918024828.htm Scientists have identified the genetic cause behind the mysterious AnWj blood group antigen, solving a puzzle that began in 1972 and establishing a new blood group system called MAL. The discovery could make it much easier to find extremely rare AnWj-negative patients and donors and protect them from potentially dangerous transfusion reactions. Sat, 19 Sep 2026 06:14:15 EDT https://www.sciencedaily.com/releases/2026/09/260918024828.htm https://www.sciencedaily.com/releases/2026/09/260912220051.htm Scientists found that the 3D organization of DNA is disrupted in several types of brain cells affected by Alzheimer’s disease, altering how important genes are switched on and off. The discovery reveals a previously underexplored layer of the disease that could open new paths for understanding and eventually treating Alzheimer’s. Sun, 13 Sep 2026 09:56:06 EDT https://www.sciencedaily.com/releases/2026/09/260912220051.htm https://www.sciencedaily.com/releases/2026/09/260909231800.htm A remarkably detailed study of Maria Branyas, who lived past 117, reveals that extreme longevity may involve both intense aging and powerful biological protection at the same time. Researchers found signs of advanced aging, but also low inflammation, beneficial gut bacteria, protective genetic features, and a biological age younger than her chronological age. Because she avoided major disease, the study offered a rare look at aging itself rather than the illnesses that often accompany it. Fri, 11 Sep 2026 00:27:25 EDT https://www.sciencedaily.com/releases/2026/09/260909231800.htm https://www.sciencedaily.com/releases/2026/09/260901070518.htm “Broken heart syndrome” can mimic a heart attack so closely that patients often need invasive testing to tell the difference. Researchers have now developed the BioTAK score, which combines biological sex with blood biomarkers to identify the condition before cardiac catheterization. In a validation study of nearly 1,800 patients, it correctly classified almost 90% of participants. Wed, 02 Sep 2026 11:03:43 EDT https://www.sciencedaily.com/releases/2026/09/260901070518.htm https://www.sciencedaily.com/releases/2026/08/260826055508.htm Moderate calorie restriction lowered an immune protein called C3 that appears to help drive chronic inflammation as the body ages. Blocking the same protein reduced age related inflammation in mice, raising the possibility that future treatments could mimic some benefits of calorie restriction without severe dieting. Wed, 26 Aug 2026 09:00:53 EDT https://www.sciencedaily.com/releases/2026/08/260826055508.htm https://www.sciencedaily.com/releases/2026/08/260819041220.htm Scientists have found evidence that the effects of a mother’s age on her offspring may be driven by reversible changes in gene activity rather than permanent DNA damage. The discovery raises the fascinating possibility that biological information from mothers, grandmothers, and even great-grandmothers can shape the health of future generations. Wed, 19 Aug 2026 19:44:38 EDT https://www.sciencedaily.com/releases/2026/08/260819041220.htm https://www.sciencedaily.com/releases/2026/08/260816044842.htm Silver nanoparticles can precisely slice DNA and create longer “sticky ends,” helping genetic fragments join up to five times more efficiently than conventional methods. The breakthrough could eventually simplify the construction of large DNA sequences for gene therapies, cancer vaccines, engineered drugs, and advanced crops. Wed, 19 Aug 2026 03:46:13 EDT https://www.sciencedaily.com/releases/2026/08/260816044842.htm https://www.sciencedaily.com/releases/2026/08/260812015214.htm Researchers have discovered that a gene linked to congenital heart disease acts like an architect for the heart cell’s DNA. Losing just one copy of TBX5 can cause the genome’s carefully folded 3D structure to unravel, disrupting the genes needed to build a healthy heart. The effects can vary from cell to cell, which may help explain why people with the same mutation develop different heart defects. The same hidden mechanism could also play a role in other birth defects. Thu, 13 Aug 2026 09:46:14 EDT https://www.sciencedaily.com/releases/2026/08/260812015214.htm https://www.sciencedaily.com/releases/2026/08/260810015725.htm UCLA researchers have created a blood test that can scan DNA signals for multiple cancers, liver diseases, and signs of organ damage—and even indicate where trouble may be developing. Early results suggest the inexpensive approach could bring medicine closer to a single blood test capable of catching a wide range of diseases before they become harder to treat. Mon, 10 Aug 2026 22:36:37 EDT https://www.sciencedaily.com/releases/2026/08/260810015725.htm https://www.sciencedaily.com/releases/2026/08/260801042811.htm A sweeping review of more than 350 studies suggests that the protein boom may be overselling what many people actually need. Eating less protein appears to improve metabolism, reduce inflammation and cellular damage, and activate pathways linked to healthier aging and longer life. Sun, 02 Aug 2026 00:52:01 EDT https://www.sciencedaily.com/releases/2026/08/260801042811.htm https://www.sciencedaily.com/releases/2026/07/260723084856.htm The longevity-linked APOE2 gene appears to protect brain cells by reducing DNA damage and helping neurons recover from stress. The finding could open a new path toward treatments that mimic APOE2’s defenses in people at higher genetic risk for Alzheimer’s. Fri, 24 Jul 2026 02:00:15 EDT https://www.sciencedaily.com/releases/2026/07/260723084856.htm https://www.sciencedaily.com/releases/2026/07/260713084907.htm Researchers found that semaglutide, the active ingredient in Ozempic and Wegovy, slowed biological aging markers in adults with HIV, marking the first clinical evidence that the drug may influence human aging. Although the findings are encouraging, scientists say larger studies are needed before concluding that the medication can help people age more slowly. Tue, 14 Jul 2026 05:47:41 EDT https://www.sciencedaily.com/releases/2026/07/260713084907.htm https://www.sciencedaily.com/releases/2026/07/260713000800.htm Sleeping about an hour and 20 minutes less each night for six weeks caused participants to gain weight and spend more time inactive. Researchers found that even mild, realistic sleep loss, similar to what many adults experience, had measurable effects. They warn that if this pattern continues over months or years, the health consequences could become much more significant, including a higher risk of diabetes and heart disease. Mon, 13 Jul 2026 09:24:13 EDT https://www.sciencedaily.com/releases/2026/07/260713000800.htm https://www.sciencedaily.com/releases/2026/07/260710003535.htm Researchers found that tau is essential for turning new experiences into lasting memories by helping organize the brain's memory-storing cells. The mouse study also revealed how abnormal tau may contribute to Alzheimer's by disrupting both the formation of new memories and the recall of existing ones. Sun, 12 Jul 2026 08:53:12 EDT https://www.sciencedaily.com/releases/2026/07/260710003535.htm https://www.sciencedaily.com/releases/2026/07/260708022202.htm Scientists have created a silicon chip that can write dozens of DNA sequences simultaneously using electricity and water-based enzymes, offering a cleaner alternative to conventional DNA manufacturing. The breakthrough could eventually support portable DNA-writing devices and even massive DNA data storage, although new chemistry will be needed to scale the technology further. Wed, 08 Jul 2026 22:48:06 EDT https://www.sciencedaily.com/releases/2026/07/260708022202.htm https://www.sciencedaily.com/releases/2026/07/260701205001.htm Researchers have cracked the code behind bacteria's ability to naturally manufacture multiple versions of powerful anti-cancer drugs. The discovery could make it much easier to engineer new cancer treatments inspired by nature, including improved versions of existing medicines. Wed, 08 Jul 2026 17:28:31 EDT https://www.sciencedaily.com/releases/2026/07/260701205001.htm https://www.sciencedaily.com/releases/2026/07/260701015247.htm Intermittent fasting helped people lose as much weight as calorie restriction, but without the same feeling of constantly controlling their food intake. Researchers say that difference could make fasting a more sustainable option for people who struggle with traditional diets. Wed, 08 Jul 2026 04:46:47 EDT https://www.sciencedaily.com/releases/2026/07/260701015247.htm https://www.sciencedaily.com/releases/2026/06/260602021645.htm A major study suggests that some of the groundwork for brain development may be shaped before birth through a surprising partnership between a baby’s genes and gut microbes. Researchers found that epigenetic changes present at birth can influence how the gut microbiome develops during the first year of life, and certain combinations were linked to early signs of autism and ADHD by age three. Tue, 02 Jun 2026 10:18:47 EDT https://www.sciencedaily.com/releases/2026/06/260602021645.htm https://www.sciencedaily.com/releases/2026/05/260512202345.htm A daily multivitamin may help slow biological aging, according to researchers studying older adults in a large clinical trial. After two years, participants taking multivitamins showed slower aging in several DNA-based “epigenetic clocks,” with the effect equal to about four months less biological aging. People who started out biologically older than their actual age appeared to benefit the most. The findings hint that a simple supplement could play a role in healthier aging. Thu, 14 May 2026 10:22:46 EDT https://www.sciencedaily.com/releases/2026/05/260512202345.htm https://www.sciencedaily.com/releases/2026/04/260416071951.htm Scientists have discovered that a protein linked to cell death is secretly driving the aging of blood stem cells in a completely different way. Instead of killing the cells, it damages their mitochondria, sapping their energy and weakening the immune system over time. When this protein was turned off, stem cells remained stronger and more balanced, even under stress. The findings point to a new strategy for slowing aging at its source. Thu, 16 Apr 2026 22:58:28 EDT https://www.sciencedaily.com/releases/2026/04/260416071951.htm https://www.sciencedaily.com/releases/2026/04/260409101055.htm Cancer drugs known as BET inhibitors once looked like a breakthrough, but in real patients they’ve often fallen short. New research reveals a key reason why: two closely related proteins, BRD2 and BRD4, don’t actually do the same job. Instead, BRD2 acts like a “stage manager,” preparing genes for activation, while BRD4 triggers the final step that turns them on. By blocking both at once, current drugs may be disrupting the process in unpredictable ways. Thu, 09 Apr 2026 23:42:35 EDT https://www.sciencedaily.com/releases/2026/04/260409101055.htm https://www.sciencedaily.com/releases/2026/04/260407193848.htm Researchers have developed a cutting-edge technique that uses RNA “barcodes” to map how neurons connect, capturing thousands of links with single-synapse precision. The method transforms brain mapping into a sequencing task, making it faster and more scalable than traditional approaches. In mice, it revealed surprising new connections between brain cells that were previously unknown. This could open the door to earlier detection and targeted treatment of neurological diseases. Tue, 07 Apr 2026 21:37:16 EDT https://www.sciencedaily.com/releases/2026/04/260407193848.htm https://www.sciencedaily.com/releases/2026/04/260406192919.htm A gene called KLF5 may be a key force behind the spread of pancreatic cancer—but not in the way scientists expected. Rather than mutating DNA, it rewires how genes are turned on and off, helping tumors grow and invade new areas. Researchers found it plays a major role in metastatic cells and even controls other genes linked to cancer progression. The discovery opens the door to new treatments that target cancer’s epigenetic “control system.” Tue, 07 Apr 2026 07:19:47 EDT https://www.sciencedaily.com/releases/2026/04/260406192919.htm https://www.sciencedaily.com/releases/2026/03/260331001107.htm A surprising breakthrough suggests that a drug best known as Viagra could help treat a devastating childhood disease. Researchers found that sildenafil significantly improved symptoms in patients with Leigh syndrome—a rare and often fatal disorder that affects the brain and muscles. In a small study, patients showed stronger muscles, fewer seizures, and better recovery from dangerous metabolic crises, with some experiencing dramatic improvements in mobility and daily life. Tue, 31 Mar 2026 08:33:45 EDT https://www.sciencedaily.com/releases/2026/03/260331001107.htm https://www.sciencedaily.com/releases/2026/03/260319044711.htm Aging men often lose the Y chromosome in a growing number of their cells—and it may be far more dangerous than once believed. This loss has been linked to heart disease, cancer, Alzheimer’s, and shorter lifespans. Researchers suspect Y-less cells may grow faster and disrupt normal body functions. What seemed like a minor genetic quirk could actually be a major driver of age-related disease. Thu, 19 Mar 2026 04:47:11 EDT https://www.sciencedaily.com/releases/2026/03/260319044711.htm https://www.sciencedaily.com/releases/2026/03/260309183010.htm Researchers have found hundreds of metabolic enzymes attached to human DNA inside the cell nucleus. Different tissues and cancers show unique patterns of these enzymes, forming a “nuclear metabolic fingerprint.” Some of the enzymes gather around damaged DNA to assist with repair. The discovery reveals an unexpected link between metabolism and gene regulation that could influence how cancers grow and respond to treatment. Mon, 09 Mar 2026 19:54:17 EDT https://www.sciencedaily.com/releases/2026/03/260309183010.htm https://www.sciencedaily.com/releases/2026/03/260306145621.htm Researchers have discovered a new way to increase a key brain protein damaged in Rett syndrome, a rare genetic disorder that affects thousands of children worldwide. Early studies in mice and patient-derived cells show the approach can restore normal brain cell function, raising hopes for future therapies. Fri, 06 Mar 2026 21:18:09 EST https://www.sciencedaily.com/releases/2026/03/260306145621.htm https://www.sciencedaily.com/releases/2026/02/260210040608.htm Why does the same virus barely faze one person while sending another to the hospital? New research shows the answer lies in a molecular record etched into our immune cells by both our genes and our life experiences. Scientists at the Salk Institute have created a detailed epigenetic map of human immune cells, revealing how inherited traits and past exposures—like infections, vaccines, or even environmental chemicals—shape immune responses in different ways. Wed, 11 Feb 2026 00:02:01 EST https://www.sciencedaily.com/releases/2026/02/260210040608.htm https://www.sciencedaily.com/releases/2026/02/260208233844.htm Scientists have discovered that DNA behaves in a surprising way when squeezed through tiny nanopores, overturning a long-held assumption in genetics research. What researchers once thought were knots causing messy electrical signals turn out to be something else entirely: twisted coils called plectonemes, formed as flowing ions inside the pore spin the DNA like a phone cord. These twists can linger and grow as DNA moves through, leaving clear electrical fingerprints. Mon, 09 Feb 2026 07:03:56 EST https://www.sciencedaily.com/releases/2026/02/260208233844.htm https://www.sciencedaily.com/releases/2026/01/260125083344.htm Cancer doesn’t evolve by pure chaos. Scientists have developed a powerful new method that reveals the hidden rules guiding how cancer cells gain and lose whole chromosomes—massive genetic shifts that help tumors grow, adapt, and survive treatment. By tracking thousands of individual cells over time, the approach shows which chromosome combinations give cancer an edge and why some tumors become especially resilient. Mon, 26 Jan 2026 04:41:20 EST https://www.sciencedaily.com/releases/2026/01/260125083344.htm https://www.sciencedaily.com/releases/2026/01/260122093435.htm A new study reveals that super agers over 80 have a distinct genetic edge. They are much less likely to carry the gene most associated with Alzheimer’s risk, even when compared with other healthy seniors. Researchers also found higher levels of a protective gene variant in this group. Together, the findings help explain why some people age with remarkably youthful minds. Thu, 22 Jan 2026 09:41:30 EST https://www.sciencedaily.com/releases/2026/01/260122093435.htm https://www.sciencedaily.com/releases/2026/01/260112001001.htm Most U.S. adults have risk factors tied to a little-known condition called CKM syndrome, which connects heart disease, kidney problems, diabetes, and obesity into one powerful health threat. When these issues overlap, the danger rises far more than when they occur alone. Despite low awareness, people are eager to learn how CKM is diagnosed and treated. Experts say understanding how these systems work together could prevent serious, life-threatening events. Mon, 12 Jan 2026 00:10:01 EST https://www.sciencedaily.com/releases/2026/01/260112001001.htm https://www.sciencedaily.com/releases/2026/01/260108231411.htm Although the gut renews itself constantly, its stem cells accumulate age-related molecular changes that quietly alter how genes are switched on and off. Scientists found that this “epigenetic drift” follows a clear pattern and appears in both aging intestines and most colon cancers. Some regions age faster than others, forming a patchwork of weakened tissue more prone to degeneration. Encouragingly, researchers showed this drift can be slowed—and partly reversed—by restoring iron levels or key cellular signals. Sat, 10 Jan 2026 08:17:12 EST https://www.sciencedaily.com/releases/2026/01/260108231411.htm https://www.sciencedaily.com/releases/2026/01/260107225541.htm DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave. Researchers have now mapped this hidden architecture in unprecedented detail, showing how genome structure changes from cell to cell and over time. These insights reveal why many disease-linked mutations outside genes can still cause harm. The findings could speed up the discovery of genetic risks and inspire new ways to target diseases. Thu, 08 Jan 2026 21:16:11 EST https://www.sciencedaily.com/releases/2026/01/260107225541.htm https://www.sciencedaily.com/releases/2026/01/260104202813.htm A new CRISPR breakthrough shows scientists can turn genes back on without cutting DNA, by removing chemical tags that act like molecular anchors. The work confirms these tags actively silence genes, settling a long-running scientific debate. This gentler form of gene editing could offer a safer way to treat Sickle Cell disease by reactivating a fetal blood gene. Researchers say it opens the door to powerful therapies with fewer unintended side effects. Mon, 05 Jan 2026 05:08:21 EST https://www.sciencedaily.com/releases/2026/01/260104202813.htm https://www.sciencedaily.com/releases/2025/12/251217082505.htm A missing brain molecule may be disrupting neural wiring in Down syndrome, according to new research. Replacing it in adult mice rewired brain circuits and improved brain flexibility, challenging the idea that treatment must happen before birth. Wed, 17 Dec 2025 08:25:05 EST https://www.sciencedaily.com/releases/2025/12/251217082505.htm https://www.sciencedaily.com/releases/2025/12/251209043057.htm Researchers discovered that a long-misunderstood protein plays a key role in helping chromosomes latch onto the right “tracks” during cell division. Instead of acting like a motor, it works more like a stabilizer that sets everything up correctly from the start. This simple shift in understanding changes how scientists view one of the most important steps in biology. It also highlights a potential weak point that could help explain how some diseases begin. Wed, 10 Dec 2025 09:19:47 EST https://www.sciencedaily.com/releases/2025/12/251209043057.htm https://www.sciencedaily.com/releases/2025/12/251209043050.htm New research is challenging one of medicine’s oldest assumptions: that cancer must be attacked to be cured. By treating glioblastoma patients with a simple combination of resveratrol and copper, the researchers found dramatic reductions in tumor aggressiveness, cancer biomarkers, immune checkpoints, and stem-cell–related markers—all without side effects. Their approach focuses on “healing” tumors by eliminating harmful cell-free chromatin particles released from dying cancer cells, which normally inflame and worsen the disease. The findings hint at a future where inexpensive nutraceuticals could transform cancer therapy. Wed, 10 Dec 2025 03:56:21 EST https://www.sciencedaily.com/releases/2025/12/251209043050.htm https://www.sciencedaily.com/releases/2025/11/251129053351.htm Researchers studying thousands of canine genomes discovered that wolf DNA is still present in most dog breeds. This ancient genetic influence shows up in traits like body size, behavior, and environmental resilience. Even dogs bred far from wolves, including tiny chihuahuas, carry detectable wolf ancestry. The findings highlight how deeply intertwined the histories of dogs and wolves really are. Sat, 29 Nov 2025 10:49:53 EST https://www.sciencedaily.com/releases/2025/11/251129053351.htm https://www.sciencedaily.com/releases/2025/11/251113071613.htm Scientists studying aging found that sensory inputs like touch and smell can cancel out the lifespan-boosting effects of dietary restriction by suppressing the key longevity gene fmo-2. When overactivated, the gene makes worms oddly indifferent to danger and food, suggesting trade-offs between lifespan and behavior. The work highlights how deeply intertwined the brain, metabolism, and environment are. These pathways may eventually be targeted to extend life without extreme dieting. Thu, 13 Nov 2025 07:16:13 EST https://www.sciencedaily.com/releases/2025/11/251113071613.htm https://www.sciencedaily.com/releases/2025/10/251016223110.htm EMBL researchers created SDR-seq, a next-generation tool that decodes both DNA and RNA from the same cell. It finally opens access to non-coding regions, where most disease-associated genetic variants lie. By revealing how these variants affect gene activity, scientists can better understand complex diseases and develop improved diagnostic tools. Sat, 18 Oct 2025 02:01:00 EDT https://www.sciencedaily.com/releases/2025/10/251016223110.htm https://www.sciencedaily.com/releases/2025/10/251005085628.htm Scientists studying tiny roundworms have uncovered how the secrets of a long life can be passed from parents to their offspring — without changing DNA. The discovery shows that when certain cellular structures called lysosomes change in ways that promote longevity, those benefits can travel from body cells to reproductive cells. This information is carried by histones, special proteins that help organize DNA, allowing the “memory” of those changes to be inherited. Sun, 05 Oct 2025 08:56:28 EDT https://www.sciencedaily.com/releases/2025/10/251005085628.htm https://www.sciencedaily.com/releases/2025/10/251004092858.htm A Weill Cornell Medicine team has found that triple-negative breast cancer depends on the enzyme EZH2 to spread. By silencing key genes, EZH2 drives chaotic cell divisions and fuels metastasis. Blocking EZH2 restored stability and prevented cancer cells from traveling to distant organs. This discovery opens the door to new therapies that may finally tame this aggressive disease. Sat, 04 Oct 2025 11:05:19 EDT https://www.sciencedaily.com/releases/2025/10/251004092858.htm https://www.sciencedaily.com/releases/2025/09/250928095627.htm Human fertility hinges on a delicate molecular ballet that begins even before birth. UC Davis researchers have uncovered how special protein networks safeguard chromosomes as eggs and sperm form, ensuring genetic stability across generations. Using yeast as a model, they revealed how crossovers between chromosomes are protected for decades in female eggs, preventing errors that could lead to infertility, miscarriage, or conditions like Down syndrome. Sun, 28 Sep 2025 22:37:58 EDT https://www.sciencedaily.com/releases/2025/09/250928095627.htm https://www.sciencedaily.com/releases/2025/09/250921090904.htm New research shows that cancer cells don’t just grow; they adapt when stressed. When squeezed inside tissues, they transform into more invasive, drug-resistant versions of themselves. A protein called HMGB2 helps flip this dangerous switch, giving the cells new powers to escape. The findings reveal how the tumor’s environment itself can drive cancer’s deadly flexibility. Mon, 22 Sep 2025 07:40:43 EDT https://www.sciencedaily.com/releases/2025/09/250921090904.htm https://www.sciencedaily.com/releases/2025/08/250831010510.htm New research suggests that exercise may not just make us feel younger—it could actually slow or even reverse the body’s molecular clock. By looking at DNA markers of aging, scientists found that structured exercise like aerobic and strength training has stronger anti-aging effects than casual activity. Evidence from both mice and humans shows measurable reductions in biological age, with benefits reaching beyond muscles to the heart, liver, fat tissue, and gut. Sun, 31 Aug 2025 05:00:21 EDT https://www.sciencedaily.com/releases/2025/08/250831010510.htm https://www.sciencedaily.com/releases/2025/08/250826005229.htm Scientists at Kyoto University have uncovered a hidden protein complex that organizes DNA in sperm stem cells, a discovery that reveals surprising ties between fertility and cancer. When this protein, called STAG3, is missing, sperm stem cells cannot mature properly, leading to infertility in mice. Even more intriguing, the same protein is found in high levels in certain immune cells and cancers, and blocking it slowed tumor growth in the lab. Tue, 26 Aug 2025 23:06:39 EDT https://www.sciencedaily.com/releases/2025/08/250826005229.htm https://www.sciencedaily.com/releases/2025/08/250806100753.htm Scientists discovered that jewel wasp larvae that undergo a developmental "pause" live longer and age more slowly at the molecular level by nearly 30%. This slowdown is tied to conserved biological pathways, hinting at possible applications for human aging. Thu, 07 Aug 2025 23:00:34 EDT https://www.sciencedaily.com/releases/2025/08/250806100753.htm https://www.sciencedaily.com/releases/2025/07/250718031218.htm In a groundbreaking UK first, eight healthy babies have been born using an IVF technique that includes DNA from three people—two parents and a female donor. The process, known as pronuclear transfer, was designed to prevent the inheritance of devastating mitochondrial diseases passed down through the mother’s DNA. The early results are highly promising: all the babies are developing normally, and the disease-causing mutations are undetectable or present at levels too low to cause harm. For families once haunted by genetic risk, this science offers more than treatment—it offers transformation. Fri, 18 Jul 2025 10:05:48 EDT https://www.sciencedaily.com/releases/2025/07/250718031218.htm https://www.sciencedaily.com/releases/2025/07/250715043351.htm A new study comparing three popular diets—intermittent fasting, time-restricted eating, and continuous calorie cutting—found that all can help people with type 2 diabetes lose weight and lower blood sugar. But one diet stood out: the 5:2 intermittent fasting plan, where participants eat normally five days a week and restrict calories on two. It led to better results in fasting blood sugar, insulin response, and sticking with the plan. Tue, 15 Jul 2025 08:30:36 EDT https://www.sciencedaily.com/releases/2025/07/250715043351.htm https://www.sciencedaily.com/releases/2025/07/250705084324.htm A group of scientists studying pregnancy across six different mammals—from humans to marsupials—uncovered how certain cells at the mother-baby boundary have been working together for over 100 million years. By mapping gene activity in these cells, they found that pregnancy isn’t just a battle between mother and fetus, but often a carefully coordinated partnership. These ancient cell interactions, including hormone production and nutrient sharing, evolved to support longer, more complex pregnancies and may help explain why human pregnancy works the way it does today. Sun, 06 Jul 2025 07:22:19 EDT https://www.sciencedaily.com/releases/2025/07/250705084324.htm https://www.sciencedaily.com/releases/2025/06/250620231852.htm USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer's in people with Down syndrome: iron overload in the brain. Their study revealed that individuals with both conditions had twice the iron levels and far more oxidative damage than others. The culprit appears to be ferroptosis, an iron-triggered cell death mechanism, which is especially damaging in sensitive brain regions. Fri, 20 Jun 2025 23:18:52 EDT https://www.sciencedaily.com/releases/2025/06/250620231852.htm https://www.sciencedaily.com/releases/2025/06/250619090901.htm Intermittent fasting might not be a miracle solution, but it stands shoulder to shoulder with traditional calorie-cutting when it comes to shedding pounds and improving metabolic health. A major new analysis reveals that alternate day fasting may have a slight edge, yet none of the methods alone reached clinically meaningful thresholds for weight loss. Thu, 19 Jun 2025 09:09:01 EDT https://www.sciencedaily.com/releases/2025/06/250619090901.htm https://www.sciencedaily.com/releases/2025/06/250607231509.htm A powerful new discovery reveals that Nup98 a protein once thought to only ferry molecules through the nucleus plays a vital role in safeguarding the most vulnerable areas of DNA. By forming droplet-like 'bubbles' around damaged DNA within dense regions called heterochromatin, Nup98 safely escorts the damaged segments to repair zones and times the involvement of risky repair proteins. This precise choreography prevents genetic errors that could trigger cancer or speed up aging. Sat, 07 Jun 2025 23:15:09 EDT https://www.sciencedaily.com/releases/2025/06/250607231509.htm https://www.sciencedaily.com/releases/2025/05/250529124849.htm SAVANA uses a machine learning algorithm to identify cancer-specific structural variations and copy number aberrations in long-read DNA sequencing data. The complex structure of cancer genomes means that standard analysis tools give false-positive results, leading to erroneous clinical interpretations of tumour biology. SAVANA significantly reduces such errors. SAVANA offers rapid and reliable genomic analysis to better analyse clinical samples, thereby informing cancer diagnosis and therapeutic interventions. Thu, 29 May 2025 12:48:49 EDT https://www.sciencedaily.com/releases/2025/05/250529124849.htm https://www.sciencedaily.com/releases/2025/05/250529124615.htm Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA and creates specific loops in the genetic material which determine the architecture of the genome and gene expression. Some mutations in the genes of the cohesion complex are responsible for rare diseases (cohesinopathies), such as the Cornelia de Lange syndrome (SCdL) or Roberts syndrome, which affect several organs and cause malformations during development. Thu, 29 May 2025 12:46:15 EDT https://www.sciencedaily.com/releases/2025/05/250529124615.htm https://www.sciencedaily.com/releases/2025/05/250528131843.htm Researchers find high-fat diets set off metabolic dysfunction in cells, leading to weight gain, but these effects can be reversed by treatment with an antioxidant. Wed, 28 May 2025 13:18:43 EDT https://www.sciencedaily.com/releases/2025/05/250528131843.htm https://www.sciencedaily.com/releases/2025/05/250527124537.htm A biobank for pediatric kidney tumors plays a key role in identifying hereditary causes of Wilms tumors. New insights gained with its help enable better risk assessment for affected families and could form the basis for targeted screening and improved early detection. Tue, 27 May 2025 12:45:37 EDT https://www.sciencedaily.com/releases/2025/05/250527124537.htm https://www.sciencedaily.com/releases/2025/05/250522125200.htm The bacteria that cause tuberculosis (TB) may have an 'on-off switch' that lets them pause and restart growth, according to a new study. The research helps explain why TB is so hard to treat with antibiotics and could pave the way for better drugs. Thu, 22 May 2025 12:52:00 EDT https://www.sciencedaily.com/releases/2025/05/250522125200.htm https://www.sciencedaily.com/releases/2025/05/250521124301.htm A study explains how age reshapes the blood system. In both humans and mice, a few stem cells out-compete their neighbors and gradually take over blood production. The loss of diversity results in a blood system that has a preference for producing myeloid cells, immune cells linked to chronic inflammation which underlies many different diseases. Using a new technique, researchers tracked naturally-occurring 'barcodes' in blood cells which can lead to new strategies that spot early warning signs of unhealthy aging long before symptoms appear, helping prevent cancer or heart disease. The technique also opens the door to studying the viability of rejuvenation therapies in humans, efforts which have traditionally been the focus of animal research. Wed, 21 May 2025 12:43:01 EDT https://www.sciencedaily.com/releases/2025/05/250521124301.htm