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predispose

American  
[pree-di-spohz] / ˌpri dɪˈspoʊz /

verb (used with object)

  • predisposes,
    present (3rd person singular)
  • predisposed,
    past participle,  past
  • predisposing
    present participle
  1. to give an inclination or tendency to beforehand; make susceptible.

    Genetic factors may predispose human beings to certain metabolic diseases.

    Synonyms:
    prepare, prearrange
  2. to render subject, susceptible, or liable.

    The evidence predisposes him to public censure.

  3. to dispose beforehand.

    Synonyms:
    incline, bias
  4. Archaic. to dispose of beforehand, as in a will, legacy, or the like.


verb (used without object)

  • predisposes,
    present (3rd person singular)
  • predisposed,
    past participle,  past
  • predisposing
    present participle
  1. to give or furnish a tendency or inclination.

    an underground job that predisposes to lung infection.

predispose British  
/ ˌpriːdɪˈspəʊz /

verb

  1. to incline or make (someone) susceptible to something beforehand

  2. law to dispose of (property, etc) beforehand; bequeath

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

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Etymology

Origin of predispose

First recorded in 1640–50; pre- + dispose

Explanation

Predispose means to have a tendency toward something. Some people believe that just being born in Canada will predispose you to love ice hockey. Many situations or events can predispose you to have a particular reaction, opinion, or feeling. Being bitten by a dog as a child could predispose you to having a fear of dogs. Having ancestors with great athletic ability might predispose you to enjoy running. If you want to predispose your father to liking your new boyfriend, be sure to tell him about volunteering at the food bank and leave out the bits about his arrest and dropping out of school.

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Vocabulary lists containing predispose

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Recognizing this, some oncologists have begun administering drugs with restraint rather than abandon, aiming to keep the cancer in check rather than creating conditions that predispose to the rapid growth of resistant cells.

From The Wall Street Journal Apr. 20, 2026

"The whole team undertakes a standardized warm-up that addresses a number of physical concerns that predispose our female athletes to ACLs," she said.

From BBC Jun. 30, 2025

Nothing in her environment would predispose her to cancer, except for being in close proximity to the fires.

From Slate Jan. 16, 2025

Researchers are currently focused on understanding the underlying biological pathways leading to long COVID, along with potential biological markers that predispose some individuals to long COVID.

From Salon Dec. 21, 2024

Attitudes such as these certainly predispose one to innumeracy.

From "Innumeracy: Mathematical Illiteracy and Its Consequences" by John Allen Paulos

The condition turns up in 10% to 20% of people in their 70s, and predisposes them to blood cancer and, surprisingly, heart disease, likely driven by the inflammation these rogue cells provoke.

From The Wall Street Journal Apr. 20, 2026

Studies show that adding sugar to any food for babies or small children predisposes them to having a sweet tooth.

From Salon Apr. 25, 2024

"On the other hand, if telomeres are too long, it predisposes you to certain types of cancer."

From Science Daily Apr. 11, 2024

People with two copies of the APOE4 gene, which predisposes to Alzheimer’s, may be at higher risk of ARIA.

From Science Magazine Jan. 6, 2023

Constipation certainly predisposes to it, and it appears to be more prevalent among medical men, commercial travellers, or any engaged in arduous callings, subjected to irregular meals, fatigue and exposure.

From Encyclopaedia Britannica, 11th Edition, Volume 8, Slice 4 "Diameter" to "Dinarchus" by Various

Certain breeds are predisposed to heart or orthopedic issues, for example, that can be expensive to treat.

From MarketWatch Sep. 15, 2026

Among participants assigned to the low-carb diet, those who were genetically predisposed to higher LDL cholesterol were more likely to experience an increase.

From Science Daily Aug. 26, 2026

But Lindhome is, by her own admission, naturally predisposed to find the positive in everything.

From Los Angeles Times Apr. 7, 2025

What's more, With Love, Meghan was never going to change opinions of those who are already, for whatever reason, predisposed against her - just as her new podcast series is unlikely to.

From BBC Apr. 6, 2025

As a people group, Persians are genetically predisposed to like tea.

From "Darius the Great Is Not Okay" by Adib Khorram

Fifteen potentially harmful and predisposing variants in the same RNF207 and PRKAA2 genes, which had been identified in dogs, were discovered in humans.

From Science Daily Sep. 22, 2023

But a recent study suggested that the risk of so-called long COVID-19 is highest among people with one of four predisposing factors, including Type 2 diabetes and the presence of autoantibodies.

From Seattle Times Feb. 4, 2022

Many species of Sorbus have a small population size, predisposing them to threatening events.

From BBC Sep. 26, 2021

“Climate change is predisposing the fuels into drier conditions,” Stephens said.

From Los Angeles Times Oct. 6, 2020

Was there anything about the Chinese environment predisposing toward Confucian philosophy and cultural conservatism, which may also have profoundly affected history?

From "Guns, Germs, and Steel: The Fates of Human Societies" by Jared M. Diamond

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